The Museum of Archeology Guamuhaya, founded on May 15th 1976, in a beautiful mansion on the west side of the Plaza Mayor traces pre- and post-Columbian history. It exhibits in chronological order through 8 rooms objects belonging to the aborigines living in the South Central Region of the island of Cuba during the precolumbus era, as well as material evidence of the Colonial period of very diverse origin and a bill from the city of Trinidad and Valle de los Ingenios. Some of these objects are considered unique in Cuba.

Set in the Plazuela de Jigüe, a tiny plaza shaded by one tree, is this colorful and historic restaurant (dating from 1720). An elegant Colonial-style restaurant, probably the best of Trinidad's state-run restaurants, El Jigüe (hee-gweh) is a brightly lit, nearly formal dining room in a handsome, airy colonial house. Its bright interior has high ceilings, chandeliers, and landscapes hung on white walls. The menu ranges from bistec of grilled pork to lobster in a red sauce (enchilado de langosta). The specialty, pollo al jigüe, is a Cuban version of chicken cacciatore, which comes in a clay pot with pasta and cheese and is served with salad and coffee.

Located a block to the north of the Plaza Mayor in a former convent is the Museo Nacional de Lucha Contra Bandidos (National Museum of the Struggle against Counter-Revolutionaries). The museum exhibits documents the campaign to weed out rebels who hid in the Escambray mountains in the 1960s.

A block south of Plaza Mayor stands the grand Palacio Cantero, built in 1830. It has a magnificent ladder and great neoclassical paintings performed by local and Italian artists. Painted pillars, scrolls, shells, pediments and drapes embellish the interior, eclipsing the historical artefacts and old furniture that now form the Trinidad's History Museum.