This is one of the continent's oldest cathedrals, the seat of the fourth bishopric of America, although the building that it currently occupies was built in 1922, thus reflecting the eclectic style of architecture. One of its sides houses the Ecclesiastical Museum, with a valuable collection of furniture, paintings and sacred artefacts

The most atmospheric part of the city is Old Santiago. Céspedes Park constitutes the political, religious, administrative and social center more important of the city. The attractive square is a genteel place with tall trees, gas lanterns and iron benches. In their perimeter were located by disposition of the Laws of Indias, the representative buildings of the power: Town Hall, Cathedral, the house of the governors and the mansions of the main families of the village. Parque Céspedes is dominated by its twin-towered cathedral. A basilica was built on this spot in 1528, but what you see was rebuilt in the early 19th century after a series of earthquakes and fires.

Constructed in 1516, this structure is reputed to be Cuba's oldest house one of the oldest in the Americas, although many historians now doubt that claim. Noticeable for its black-slatted balconies, it is one of Santiago's top attractions. Diego Velázquez, the Spanish conquistador who founded the city and was the island's first governor, lived upstairs. At the moment this old house works as Cuban Historical Colonial Environment's Museum, its rooms overflow with period furniture and carved woodwork and encircle­ two lovely courtyards. Inside you'll find period beds, desks, chests, and other furniture. On the first floor is a gold foundry. Memorable are the star-shape Moorish carvings on the wooden windows and balconies, and the original interior patio with its well and rain-collecting tinajón vessel. An adjacent house is filled with antiques intended to convey the French and English decorative and architectural influences—such as the radial stained glass above the courtyard doors—in the late 19th-century.

Located in front of the Céspedes Park, the Museum of Historical Cuban Atmosphere is one of the most important museums in Santiago de Cuba. The museum is constituted by two antique houses that were built in different times. One is from the 16th century while the other is from the 19th century, and both show the way of life of the centuries in which they were built. The oldest house was built in 1515 and is a gem of the colonial architecture. It was the Governor Diego Velázquez’s home and the Casa de Contratación y Fundición de Oro (Hiring House and Golden Foundry). After several changes, the house was restored in 1965 and the space was dedicated to show the way of life of the 16th, 17th and 18th centuries. The most modern house dates from the first third of the 19th century and belonged to a local family named Quesada. This house is set in the way of life of the 19th century through a series of rooms like the hallway, the 19th century patio and the garage.