Constructed in 1516, this structure is reputed to be Cuba's oldest house one of the oldest in the Americas, although many historians now doubt that claim. Noticeable for its black-slatted balconies, it is one of Santiago's top attractions. Diego Velázquez, the Spanish conquistador who founded the city and was the island's first governor, lived upstairs. At the moment this old house works as Cuban Historical Colonial Environment's Museum, its rooms overflow with period furniture and carved woodwork and encircle­ two lovely courtyards. Inside you'll find period beds, desks, chests, and other furniture. On the first floor is a gold foundry. Memorable are the star-shape Moorish carvings on the wooden windows and balconies, and the original interior patio with its well and rain-collecting tinajón vessel. An adjacent house is filled with antiques intended to convey the French and English decorative and architectural influences—such as the radial stained glass above the courtyard doors—in the late 19th-century.

Abel Santamaría Historic Park is compounded by the museum, a library and a monument in the place in which you will find the ruins of the Former Saturnino Lora Civil Hospital. The museum of the enclosure which binds together all these buildings was opened in 1973 on the occasion of the 20th anniversary of the assault to the Moncada Headquarters, and exhibits the history related to the famous assault and the trial of Fidel Castro. The monument opened in 1979 in memory of Abel Santamaría and his colleagues who were tortured and murdered after the failed raising. It has four faces in which there is a sphinx of José Martí, another of Abel Santamaría, six bayonets symbolizing justice; the solitary star and a verse of the National Anthem. The water curtain which seems to support the compound symbolizes the ideals of the young men of the Centenary Generation.

This is undoubtedly one of the city's most well-known streets. It offers an excellent natural viewing point and is the only stepped street in Cuba. It's part of the Tivoli neighborhood, where 18th-century French-colonial mansions sit side by side with 16th-century structures

The Granjita Siboney Museum is located in the road to Playa Siboney Beach, in the province of Santiago de Cuba. It is the former encampment from where the youngsters that took the Moncada Headquarters, the second military fortress in the city of Santiago de Cuba, on July 26th 1953 left. In the 7 exhibition rooms of this museum you’ll also discover the historic house, the previous preparations to the famous assault, the development and the consequences it had for Cuba. It exhibits valuable documents and personal objects of some of the intrepid young rebels. Among its most valued objects are the semiautomatic M-1 with folded butt used by the revolutionaries during the assault, sports rifle, uniforms, documents, photographs.