This Spanish-colonial mansion was the birthplace of poet José María Heredia, who, because of his pro-independence writings, is considered Cuba's first national poet. Heredia died in 1839 at age 36 while exiled in Mexico. The house, now just a fraction of its original size, displays period furniture and some of the poet's works and belongings. The home's traditional interior patio is planted with trees and plants—including orange, myrtle, palm, and jasmine—associated with Heredia's verse. A marble plaque on the house's Calle Heredia facade excerpts one of the poet's most famous works, "Niágara".

This is undoubtedly one of the city's most well-known streets. It offers an excellent natural viewing point and is the only stepped street in Cuba. It's part of the Tivoli neighborhood, where 18th-century French-colonial mansions sit side by side with 16th-century structures

Every night, the Tropicana cabaret offers its performance "Viaje al Caribe" (a Journey to the Caribbean), which narrates the history of the people of Santiago, the most Caribbean city in Cuba, where one can feel the influence of Haiti and its voodoo religion and French customs, Dominican Republic and its merengue, Jamaica and its reggae and Puerto Rico among others. Dinner and show in the same style as the famous Tropicana Cabaret from Havana. This modern facility has been elegantly decorated with traditional elements that blend-in with the lush natural vegetation surrounding the area

The cemetery of Santa Ifigenia was founded in February of 1868, to the northwest of the city of Santiago de Cuba, and it was declared National Monument February 7 1937 and ratified as such by the Revolutionary Government May 20 1979. In this cemetery lies some of the personalities’ rest more valiant and illustrate of the independence wars, as well as some outstanding figures of the art and the Cuban culture.  This cemetery is home to the majestic mausoleum of the National Hero from Cuba, José Martí. The structure is true to Martí's wishes (expressed in one of his poems) that he be buried below the flag of Cuba and surrounded by roses. Besides this mausoleum there is a modest vault in a stone brought from Sierra Maestra, in which lies Fidel’s rest. Other highlights include the tombs of Carlos Manuel de Céspedes, the Father of Our Homeland, and those who died in the Moncada Barracks attack and a memorial to Cuban soldiers who have fallen in battle.