This is one of the continent's oldest cathedrals, the seat of the fourth bishopric of America, although the building that it currently occupies was built in 1922, thus reflecting the eclectic style of architecture. One of its sides houses the Ecclesiastical Museum, with a valuable collection of furniture, paintings and sacred artefacts

This Spanish-colonial mansion was the birthplace of poet José María Heredia, who, because of his pro-independence writings, is considered Cuba's first national poet. Heredia died in 1839 at age 36 while exiled in Mexico. The house, now just a fraction of its original size, displays period furniture and some of the poet's works and belongings. The home's traditional interior patio is planted with trees and plants—including orange, myrtle, palm, and jasmine—associated with Heredia's verse. A marble plaque on the house's Calle Heredia facade excerpts one of the poet's most famous works, "Niágara".

The cemetery of Santa Ifigenia was founded in February of 1868, to the northwest of the city of Santiago de Cuba, and it was declared National Monument February 7 1937 and ratified as such by the Revolutionary Government May 20 1979. In this cemetery lies some of the personalities’ rest more valiant and illustrate of the independence wars, as well as some outstanding figures of the art and the Cuban culture.  This cemetery is home to the majestic mausoleum of the National Hero from Cuba, José Martí. The structure is true to Martí's wishes (expressed in one of his poems) that he be buried below the flag of Cuba and surrounded by roses. Besides this mausoleum there is a modest vault in a stone brought from Sierra Maestra, in which lies Fidel’s rest. Other highlights include the tombs of Carlos Manuel de Céspedes, the Father of Our Homeland, and those who died in the Moncada Barracks attack and a memorial to Cuban soldiers who have fallen in battle. 

Every night, the Tropicana cabaret offers its performance "Viaje al Caribe" (a Journey to the Caribbean), which narrates the history of the people of Santiago, the most Caribbean city in Cuba, where one can feel the influence of Haiti and its voodoo religion and French customs, Dominican Republic and its merengue, Jamaica and its reggae and Puerto Rico among others. Dinner and show in the same style as the famous Tropicana Cabaret from Havana. This modern facility has been elegantly decorated with traditional elements that blend-in with the lush natural vegetation surrounding the area